PC 111: Physical Chemistry
Fall Quarter, 2009

University of California, San Francisco
School of Pharmacy, First Year

Overall course goals:

· Students will understand basic principles of equilibrium and kinetics, and how they relate to the action of pharmaceuticals.

· Students will understand methods used to discover new drugs, and how these build upon principles of thermodynamics and kinetics.

· Students will gain practice in quantitative problem solving.

Complete Schedule

Introductory lecture (class mechanics, goals, etc.)

Grading scheme

Teaching Assistants

Chris Fuller	chris@genome.ucsf.edu	Workshops 4, 5, 6
Henry Lin	hlin017@gmail.com	Workshops 2, 3, 4
Russell Spitzer	russell.spitzer@gmail.com	Workshops 1, 3, 5
Ryan Gile	ryan.gile@gmail.com	Workshops 1, 2, 6
Angie Koo	angie.koo@ucsf.edu	Review sessions TBA
Patrick Edsall	patrick.edsall@ucsf.edu	Review sessions TBA

Block 1: Thermodynamics

Lecture Notes	Problem Sets
Introduction to thermodynamics; energy and enthalpy	Problem Set 1A Solutions
Entropy and free energy Osmotic pressure	Problem Set 1B Solutions
Equilibrium (updated 10-14-2009) Exam 1 review slides	Problem Set 1C (extra problems) Solutions
Molecular forces (updated 10-17-2009) Paper on KNI-272 (for 10-23-2009)	Problem Set 2 Solutions
Exam 1 solutions	Exam 1 “redo” solutions
Workshops	Matt Jacobson
Week of 28 Sep-2 Oct 2009: Math review Excel review	matt.jacobson@ucsf.edu
Week of 12-16 Oct, 2009: Scatchard plots Handout	Room N-472C, Genentech Hall, UCSF
Week of 26-30 Oct, 2009: Visualizing protein-ligand binding Handout: MSWord PDF	Office hours: After class on Wed, and by appointment

Block 2: Chemical Kinetics

PC 111 Chemical Kinetics Schedule and Objectives	Problem Sets
	Problem Set 3
Lecture Note Supplement	Problem Set 4
Rate Laws, Reaction Orders and Rate Constants
Complex Reaction Kinetics	Exams from the Ancient Past ... but still pertinent!
Energy Diagram for Sequential Reaction	Exams from the Ancient Past ... but still pertinent!
Transition State Theory	Midterm Exam 1994
Diffusion-controlled Reaction	Midterm Exam 1996
Ionic Reactions	Final Exam 1994
Acid-Base Catalysis	Final Exam 1996
Enzyme Kinetics and Inhibition
Workshops	Thomas L. James
Week of 2-6 November, 2009	james@picasso.ucsf.edu, 415-476-1569
Week of 9-13 November, 2009	Room S-512D, Genentech Hall, UCSF
Week of 16-20 November, 2009

Block 3: Drug Discovery

Lecture Notes
Techniques in Drug Discovery & the Role of Physical & Structural Principles
Workshops	Brian Shoichet
Week of 30 Nov – 4 Dec 2009 (Handout to come)	bshoichet@gmail.com
	Room 508D, Byers Hall, UCSF
	Office hours: After class on Wed, and by appointment